![]() ![]() ![]() The patient has normal vital signs and a normal examination. You are familiar with ethylene glycol and wonder if diethylene glycol poisoning results in similar toxicity. Case PresentationsĪ 27-year-old man with a history of depression presents after a reported ingestion of “about 8 ounces” of a workplace industrial solvent that has been identified by a shift supervisor as diethylene glycol. This issue reviews common sources of alcohol exposure, basic mechanisms of toxicity, physical examination and laboratory findings that may guide rapid assessment and management, and indications for treatment. Additional interventions include adjunctive therapies that may improve acidosis and enhance clearance of the toxic alcohol or metabolites. Treatment considerations include the antidotes fomepizole and ethanol, and hemodialysis for removal of the parent compound and its toxic metabolites. Sources of toxic alcohol exposure include ethylene glycol, methanol, diethylene glycol, propylene glycol, and isopropanol. Identifying patients with potential toxic alcohol exposure and initiating appropriate management is critical to avoid significant patient morbidity. The Reciprocal Relationship Of The Anion Gap And The Osmol Gap Over Timeįigure 3. ![]() Pathways Of Ethylene Glycol Metabolismįigure 2. Differential Diagnosis For Patients With Possible Toxic Alcohol Ingestionįigure 1. Risk Management Pitfalls In Management Of Toxic Alcohol IngestionĬlinical Pathway For Management Of Patients With Toxic Alcohol Ingestion.Toxic Alcohol Ingestion In Pregnant PatientsĬontroversies In The Management Of Toxic Alcohol Exposure Toxic Alcohol Ingestion In Pediatric Patients Special Circumstances And Special Populations Treatment For Diethylene Glycol IngestionĮmergency Department Evaluation Of Propylene Glycol ToxicityĮmergency Department Evaluation Of Isopropanol Ingestion Emergency Department Evaluation Of Ethylene Glycol IngestionĮmergency Department Evaluation Of Methanol IngestionĮmergency Department Evaluation Of Diethylene Glycol Ingestion ![]()
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